Journal
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
Volume 40, Issue 9, Pages 796-802Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1745-7270.2008.00463.x
Keywords
salidroside; hydrogen peroxide; apoptosis; PC12 cells
Categories
Funding
- Teaching and Research Award Program [2002-383]
- Program for New Century Excellent Talents in University [NCET-04-0506]
- Traditional Chinese Medicine Research Foundation of Science and Technology [04-05ZP33]
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We used a rat pheochromocytoma (PC12) cell line to study the effects of salidroside on hydrogen peroxide (H2O2)-induced apoptosis. In PC12 cells, H2O2-induced apoptosis was accompanied by the down-regulation of Bcl-2, the up-regulation of Bax, the release of mitochondrial cytochrome c to cytosol, and the activation of caspase-3, -8 and -9. However, salidroside suppressed the down-regulation of Bcl-2, the up-regulation of Bax and the release of mitochondrial cytochrome c to cytosol. Moreover, salidroside attenuated caspase-3, -8 and -9 activation, and eventually protected cells against H2O2-induced apoptosis. Taken together, these results suggest that treatment of PC12 cells with salidroside can block H2O2-induced apoptosis by regulating Bcl-2 family members and by suppressing cytochrome c release and caspase cascade activation.
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