Journal
NATURE REVIEWS CANCER
Volume 11, Issue 6, Pages 426-437Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrc3066
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Funding
- Deutsche Forschungsgemeinschaft
- Deutsche Krebshilfe
- BMBF
- Erich und Gertrud RoggenbuckStiftung
- Sheldon and Miriam Adelson Foundation
- Melanoma Research Alliance [BCTR0707528, 16IB-0076]
- US National Institutes of Health [NCI R33, PO1 CA29605, CA12582]
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DNA, mRNA and microRNA are released and circulate in the blood of cancer patients. Changes in the levels of circulating nucleic acids have been associated with tumour burden and malignant progression. In the past decade a wealth of information indicating the potential use of circulating nucleic acids for cancer screening, prognosis and monitoring of the efficacy of anticancer therapies has emerged. In this Review, we discuss these findings with a specific focus on the clinical utility of cell-free nucleic acids as blood biomarkers.
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