Journal
ACS NANO
Volume 12, Issue 8, Pages 7601-7612Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.7b07439
Keywords
carbon nanotubes; alignment; reduce; hypertrophic scar; mechanism
Categories
Funding
- Foundation of Ministry of Science and Technology of the People's Republic of China [2016YFA0203302, 2011CB932503]
- National Natural Science Foundation of China [8141101156, 21225417, 31271031, 312111282]
- Natural Science Foundation of Shanghai [15ZR1412500]
- Science and Technology Commission of Shanghai Municipality [12 nm0503200, 15XD1500400]
- Shanghai Municipal Science and Technology Commission Key Program [15411950600]
- Fok Ying Tong Education Foundation
- Municipal Human Resources Development Program for Outstanding Leaders in Medical Disciplines in Shanghai [2017BR011]
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Hypertrophic scars, characterized by excessive cell proliferation, disordered cell growth, and aberrant deposition of collagens, could cause significant clinical problems. Herein, aligned carbon nanotubes (ACNTs) were synthesized via chemical vapor deposition, and bulk ACNTs were pulled out from the arrays. The capacity of the ACNTs to reduce hypertrophic scar formation was evaluated both in vitro and in vivo. The results demonstrated that the ACNTs suppressed the over proliferation of fibroblast cells, directed their growth, and inhibited collagen expression in vitro without cell cytotoxicity. Moreover, in vivo evaluation in a rabbit ear model indicated relieved scar hypertrophy after the ACNTs treatment. The gene expression microarray was further used to understand the mechanism, which showed that ACNTs could inhibit the TGF beta pathway to alter the components in the extracellular matrix, cell proliferation, cell cytoskeleton, and cell motility. These findings may provide a potent strategy of using carbon nanotubes in the bioengineering field.
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