Journal
ACS NANO
Volume 12, Issue 8, Pages 8214-8223Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.8b03368
Keywords
nanomatryoshka; magnetic resonance; contrast agent; fluorescence; photostability
Categories
Funding
- J. Evans Attwell-Welch Fellowship [L-C-0004]
- Robert A. Welch Foundation [C-1220, C-1222]
- FAPESP [2014/13645-2]
- NIH/NCI [P30CA016672]
- NIH [RO1CA159042]
- NATIONAL CANCER INSTITUTE [P30CA016672] Funding Source: NIH RePORTER
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Engineering a compact, near-infrared plasmonic nanostructure with integrated image-enhancing agents for combined imaging and therapy is an important nanomedical challenge. Recently, we showed that Au@SiO2@Au nanomatryoshkas (NM) are a highly promising nanostructure for hosting either T-1 MRI or fluorescent contrast agents with a photothermal therapeutic response 3 in a compact geometry. Here, we show that a near-infrared resonant NM can provide simultaneous contrast enhancement for both T-1 magnetic resonance imaging (MRI) and fluorescence optical imaging (FOI) by encapsulating both types of contrast agents in the internal silica layer between the Au core and shell. We also show that this method of T-1 enhancement is even more effective for Fe(III), a potentially safer contrast agent compared to Gd(III). Fe-NM-based contrast agents are found to have relaxivities 2x greater than those found in the widely used gadolinium chelate, Gd(III) DOTA, providing a practical alternative that would eliminate Gd(III) patient exposure entirely. This dual-modality nanostructure can enable not only tissue visualization with MRI but also fluorescence-based nanoparticle tracking for quantifying nanoparticle distributions in vivo, in addition to a near-infrared photothermal therapeutic response.
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