Journal
ACS NANO
Volume 8, Issue 4, Pages 3992-4003Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn5009148
Keywords
2D materials; MoS2; biosensor; dichalcogenides; field-effect transistor; label-free; pH sensor
Categories
Funding
- National Science Foundation [CCF-1162633, DGE-1144085]
- MRSEC Program of the NSF [DMR 1121053]
- Direct For Computer & Info Scie & Enginr [1162633] Funding Source: National Science Foundation
- Division of Computing and Communication Foundations [1162633] Funding Source: National Science Foundation
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Biosensors based on field-effect transistors (FETs) have attracted much attention, as they offer rapid, inexpensive, and label-free detection. While the low sensitivity of FET biosensors based on bulk 3D structures has been overcome by using 1D structures (nanotubes/nanowires), the latter face severe fabrication challenges, impairing their practical applications. in this paper, we introduce and demonstrate FET biosensors based on molybdenum disulfide (MoS2), which provides extremely high sensitivity and at the same time offers easy patternability and device fabrication, due to its 2D atomically layered structure. A MoS2-based pH sensor achieving sensitivity as high as 713 for a pH change by 1 unit along with efficient operation over a wide pH range (3-9) is demonstrated. Ultrasensitive and specific protein sensing is also achieved with a sensitivity of 196 even at 100 femtomolar concentration. While graphene is also a 2D material, we show here that it cannot compete with a MoS2-based FET biosensor, which surpasses the sensitivity of that based on graphene by more than 74-fold. Moreover, we establish through theoretical analysis that MoS2 is greatly advantageous for biosensor device scaling without compromising its sensitivity, which is beneficial for single molecular detection. Furthermore, MoS2, with its highly flexible and transparent nature, can offer new opportunities In advanced diagnostics and medical prostheses. This unique fusion of desirable properties makes MoS2 a highly potential candidate for next-generation low-cost biosensors.
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