Journal
ACS NANO
Volume 8, Issue 4, Pages 3876-3883Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn500722y
Keywords
polydopamine; multifunctional nanocomposites; mRNA recognition; magnetic resonance imaging; photoacoustic imaging; photothermal therapy
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Funding
- National Basic Research Program of China [2010CB732403, 2013CB733802, 2014CB744503]
- National Natural Science Foundation of China [21125524, 51273165, 81101101]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1116]
- Program for New Century Excellent Talents in University [NCET-13-0502]
- National Science Foundation of Fujian Province [2010J06003]
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Multifunctional nanocomposites have the potential to integrate sensing, diagnostic, and therapeutic functions into a single nanostructure. Herein, we synthesize Fe3O4@polydopamine core shell nanocomposites (Fe3O4@PDA NCs) through an in situ self-polymerization method. Dopamine, a melanin-like mimic of mussel adhesive proteins, can self-polymerize to form surface-adherent polydopamine (PDA) films onto a wide range of materials including Fe3O4 nanoparticles used here. In such nanocomposites, PDA provides a number of advantages, such as near-infrared absorption, high fluorescence quenching efficiency, and a surface for further functionalization with biomolecules. We demonstrate the ability of the Fe3O4@PDA NCs to act as theranostic agents for intracellular mRNA detection and multimodal imaging-guided photothermal therapy. This work would stimulate interest in the use of PDA as a useful material to construct multifunctional nanocomposites for biomedical applications.
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