Journal
ACS NANO
Volume 8, Issue 6, Pages 5610-5621Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn406484b
Keywords
single-walled carbon nanotubes; peroxynitrite; biodegradation; lung
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Funding
- National Institute for Occupational Safety and Health (NIOSH) [OH008282]
- National Institutes of Health, NIEHS [R01ES019304, U19AI068021, PO1HL114453]
- RFBR [12-04-01293]
- EPA STAR Graduate Fellowship [FP-91713801]
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In contrast to short-lived neutrophils, macrophages display persistent presence in the lung of animals after pulmonary exposure to carbon nanotubes. While effective in the clearance of bacterial pathogens and injured host cells, the ability of macrophages to digest carbonaceous nanoparticles has not been documented. Here, we used chemical, biochemical, and cell and animal models and demonstrated oxidative biodegradation of oxidatively functionalized single-walled carbon nanotubes via superoxide/NO* -> peroxynitrite-driven oxidative pathways of activated macrophages facilitating clearance of nanoparticles from the lung.
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