Journal
ACS NANO
Volume 8, Issue 7, Pages 6748-6755Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn5006478
Keywords
corona-free NPs; hydrophobicity; cellular uptake; hemolysis; interfacial tension; sedimentation; dynamic light scattering
Categories
Funding
- NIH [EB014277]
- Center for Hierarchical Manufacturing [CMMI-1025020]
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A protein corona is formed at the surface of nanoparticles in the presence of biological fluids, masking the surface properties of the particle and complicating the relationship between chemical functionality and biological effects. We present here a series of zwitterionic NPs of variable hydrophobidty that do not adsorb proteins at moderate levels of serum protein and do not form hard coronas at physiological serum concentrations. These particles provide platforms to evaluate nanobiological behavior such as cell uptake and hemolysis dictated directly by chemical motifs at the nanoparticle surface.
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