Journal
ACS NANO
Volume 8, Issue 12, Pages 12292-12299Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn506257c
Keywords
fluoride-driven; gate; 4-aminophenylboronic acid; nanochannel
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Funding
- National Research Fund for Fundamental Key Projects [2011CB935703, 2011CB935704]
- National Natural Science Foundation [21171171, 21434003, 91427303, 21201170, 91127025, 21121001]
- Key Research Program of the Chinese Academy of Sciences [KJZD-EW-M01]
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Fluorine is one of the human bodys required trace elements. Imbalanced fluoride levels severely affect the normal functioning of living organisms. In this article, an anion-regulated synthetic nanochannel is described. A fluoride-driven ionic gate was developed by immobilizing a fluoride-responsive functional molecule, 4-aminophenylboronic acid, onto a single conical polyimide nanochannel. When the ionic gate was in the presence of fluoride, the boron bound F-, and the hybridization of the boron center changed from sp(2) to sp(3). Thus, negatively charged monofluoride adduct (RB(OH)(2)F-), difluoride adduct (RB(OH)F-2(-)), and trifluoride adduct (RBF3-) modified surfaces with different wettability would be formed successively by increasing the concentration of F-. On the basis of the variation of surface charge and wettability, the nanochannel can actualize reversible switching between the off state and the on state in the absence and presence of F-, respectively. As an anion-regulated synthetic nanochannel, this fluoride-driven ionic gate was characterized by measuring ionic current, which possesses high sensitivity, fine selectivity, and strong stability. Thus, this gate may show great promise for use in biosensors, water quality monitoring, and drug delivery.
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