4.8 Article

Smart Nanocarrier: Self-Assembly of Bacteria-like Vesicles with Photoswitchable Cilia

Journal

ACS NANO
Volume 8, Issue 11, Pages 11341-11349

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/nn5042366

Keywords

controlled release; photoresponsive; self-assembly; vesicle; bioinspired structure; azobenzene; cyclodextrin

Funding

  1. National Natural Science Foundation of China [21422302, 21173011, 21273013, 51121091]
  2. National Basic Research Program of China (973 Program) [2013CB933800]
  3. Doctoral Program of Higher Education of China

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Bioinspired cell deformation aids in the design of smart functional molecular self-assemblies. We report on a system of bacteria-like vesicles which release entrapped drug upon developing hairs triggered by UV irradiation, just like cilia stretching from the surface of bacteria. The formation of cilia leads to a less intact membrane, which allows release of entrapped drug. This bioinspired design created a smart nanocarrier that releases the payload via deformation rather than complete breaking.

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