Journal
ACS NANO
Volume 8, Issue 6, Pages 6372-6381Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn501871d
Keywords
nanomatryoshka; multilayer nanoshells Au/SiO2/Au; photothermal therapy; near-infrared; Au nanoparticle
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Funding
- National Science Foundation [NSF-MRI-ECCS-1040470]
- National Institute of Health [NIH-ROI 5R01 CA151962, NIH UO1 CA151886]
- National Cancer Institute, Breast Cancer Research Foundation [15 P30CA125123, P50 CA58183]
- Research Grant and Susan G. Komen for the Cure Foundation Promise Grant [PG12221410]
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Au nanoparticles with plasmon resonances in the near-infrared (NIR) region of the spectrum efficiently convert light into heat, a property useful for the photothermal ablation of cancerous tumors subsequent to nanoparticle uptake at the tumor site. A critical aspect of this process is nanoparticle size, which influences both tumor uptake and photothermal efficiency. Here, we report a direct comparative study of similar to 90 nm diameter Au nanomatryoshkas (Au/SiO2/Au) and similar to 150 nm diameter Au nanoshells for photothermal therapeutic efficacy in highly aggressive triple negative breast cancer (TNBC) tumors in mice. Au nanomatryoshkas are strong light absorbers with 77% absorption efficiency, while the nanoshells are weaker absorbers with only 15% absorption efficiency. After an intravenous injection of Au nanomatryoshkas followed by a single NIR laser dose of 2 W/cm(2) for 5 min, 83% of the TNBC tumor-bearing mice appeared healthy and tumor free >60 days later, while only 33% of mice treated with nanoshells survived the same period. The smaller size and larger absorption cross section of Au nanomatryoshkas combine to make this nanoparticle more effective than Au nanoshells for photothermal cancer therapy.
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