Journal
ACS NANO
Volume 8, Issue 5, Pages 4754-4760Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn501694n
Keywords
nanopore; DNA; translocation; conductance blockade; single molecule
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Funding
- Wake Forest University School of Medicine
- Dr. Arthur and Bonnie Ennis Foundation, Decatur, IL
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Solid-state nanopore electrical signatures can be convoluted and are thus challenging to Interpret. In order to better understand the origin of these conductance changes, we investigate the translocation of DNA through small, thin pores over a range of voltage. We observe multiple, discrete populations of conductance blockades that vary with applied voltage. To describe our observations, we develop a simple model that is applicable to solid-state nanopores generally. These results represent an important step toward understanding the dynamics of the electrokinetic translocation process.
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