Journal
ACS NANO
Volume 8, Issue 4, Pages 3913-3920Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn500810n
Keywords
biomaterials; emulsions; fluorosurfactant; microdroplets; microfluidics
Categories
Funding
- NIH [EB015300, AI096305]
- NSF [EEC-0425626]
- National Science Council in Taiwan [NSC 100-2917-I-564-035]
- Danish Research Council [116325/FTP]
- Lundbeck Foundation in Denmark [R95-A10275]
- National University of Singapore (NUS-OGS)
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Microemulsion represents an attractive platform for fundamental and applied biomedical research because the emulsified droplets can serve as millions of compartmentalized micrometer-sized reactors amenable to high-throughput screening or online monitoring. However, establishing stable emulsions with surfactants that are compatible with biological applications remains a significant challenge. Motivated by the lack of commercially available surfactants suitable for microemulsion-based biological assays, this study describes the facile synthesis of a biocompatible fluorosurfactant with nonionic tris(hydroxymethyl)methyl (Iris) polar head groups. We have further demonstrated compatibility of the developed surfactant with diverse emulsion-based applications, including DNA polymeric nanoparticle synthesis, enzymatic activity assay, and bacterial or mammalian cell culture, in the setup of both double- and multiphases of emulsions.
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