Journal
ACS NANO
Volume 8, Issue 8, Pages 8363-8373Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn502858b
Keywords
nanosensor; stimuli-responsive; phase change material; photoacoustic imaging; J-aggregate; thermochromism
Categories
Funding
- Terry Fox Research Institute
- Natural Sciences and Engineering Research Council of Canada
- Canadian Institutes for Health Research
- Ontario Institute for Cancer Research
- Prostate Cancer Canada
- Canadian Foundation of Innovation
- Joey and Toby Tanenbaum/Brazilian Ball Chair in Prostate Cancer Research
- Campbell Family Institute for Cancer Research
- Princess Margaret Hospital Foundation
- Ontario Ministry of Health and Long-Term Planning
Ask authors/readers for more resources
Photoacoustic imaging provides high-resolution images at depths beyond the optical diffusion limit. To broaden its utility, there is need for molecular sensors capable of detecting environmental stimuli through alterations in photoacoustic signal. Photosynthetic organisms have evolved ingenious strategies to optimize light absorption through nanoscale ordered dye aggregation. Here, we use this concept to synthesize a stimuli-responsive nanoswitch with a large optical absorbance and sensing capabilities. Ordered dye aggregation between light harvesting porphyrins was achieved through intercalation within thermoresponsive nanovesicles. This causes an absorbance red shift of 74 nm and a 2.7-fold increase in absorptivity of the Q(y)-band, with concomitant changes in its photoacoustic spectrum. This spectral feature can be reversibly switched by exceeding a temperature threshold. Using this thermochromic property, we noninvasively determined a localized temperature change in vivo, relevant for monitoring thermal therapies of solid tumors. Similar strategies may be applied alongside photoacoustic imaging, to detect other stimuli such as pH and enzymatic activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available