Journal
ACS NANO
Volume 8, Issue 7, Pages 7370-7376Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn5024818
Keywords
gold nanorod; magnetite nanoparticle; oleate; high-density lipoprotein; internalization; photothermal effect
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Funding
- World Premier International Research Center Initiative (WPI), MEXT, Japan
- PRESTO, JST
- MEXT
- [nano-001]
- Grants-in-Aid for Scientific Research [26286027] Funding Source: KAKEN
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Surface engineering of mesoscopic metal nanoparticles to increase biocompatibility and cell interaction is important for improvement of their therapeutic properties. Here, we describe a strategy to stabilize mesoscopic metal nanoparticles and to enhance their cell interaction by stepwise addition of (Z)-9-octadecenoate (oleate) and a cell-penetrating peptide-fused high-density lipoprotein (cpHDL). Oleate replaces a cytotoxic dispersant on the surface of gold nanorods (AuNRs), which enables subsequent cpHDL binding without causing aggregation. Notably, these two lipidic dispersants are probably intercalated on the surface. This procedure was also used to stabilize 20 nm spherical gold nanoparticles and 40 nm aggregates of 10 nm magnetite nanoparticles. cpHDL-bound AuNRs were internalized greater than 80 times more efficiently than poly(ethylene glycol)-conjugated AuNRs and were able to elicit cancer cell photoablation.
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