Journal
ACS NANO
Volume 8, Issue 5, Pages 4771-4781Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn5006254
Keywords
RNA nanotechnology; 3WJ motif; RNA nanoparticles; anionic polymer; thermostable RNA; nanobiotechnology; RNA therapeutics; RNA polymer
Categories
Funding
- NIH SIG program
- UNMC Program of ENRI
- NIH [EB003730, CA151648]
- William Fairish Endowment Fund
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RNA is a polyribonucleic add belonging to a special class of anionic polymers, holding a unique property of self-assembly that is controllable in the construction of structures with defined size, shape, and stoichiometry. We report here the use of RNA as polymers to fabricate boiling-resistant triangular nanoscaffolds, which were used to construct hexagons and patterned hexagonal arrays. The RNA triangular scaffolds demonstrated promising potential to construct fluorogenic probes and therapeutic agents as functionalization with siRNA, ribozyme, folate, and fluorogenic RNA aptamers revealed independent functional activity of each RNA moiety. The ribozyme was able to cleave hepatitis genomic RNA fragments, the siRNA silenced the target genes, and all fluorogenic RNA aptamers retained their fluorescence emission property. The creation of boiling-temperature-resistant RNA nanoparticles opens a new dimension of RNA is a special polymer, feasible in industrial and nanotechnological applications.
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