Journal
ACS NANO
Volume 8, Issue 2, Pages 1639-1646Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn405961p
Keywords
ZnO nanowire arrays; graphene foam; biosensor; biomarker detection; Parkinson's disease
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Funding
- Institute for Basic Science (IBS)
- World Class University (WCU) program of the National Research Foundation of Korea (NRF) [2008-000- 10029-0]
- Ministry of Education, Science and Technology (MEST) of Korea
- Natural Science Research Foundation of China [51201052]
- Science Funds for the Young Innovative Talents of HUST [201306]
- postdoctoral science foundation of Heilongjiang province [LBH-Z11064]
- postdoctoral science foundation of China [2013M541412]
- Ministry of Science, ICT & Future Planning, Republic of Korea [IBS-R011-D1-2014-A00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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We report that vertically aligned ZnO nanowire arrays (ZnO NWAs) were fabricated on 3D graphene foam (GF) and used to selectively detect uric acid (UA), dopamine (DA), and ascorbic acid (AA) by a differential pulse voltammetry method. The optimized ZnO NWA/GF electrode provided a high surface area and high selectivity with a detection limit of 1 nM for UA and DA. The high selectivity in the oxidation potential was explained by the gap difference between the lowest unoccupied and highest occupied molecular orbitals of a biomolecule for a set of given electrodes. This method was further used to detect UA levels in the serum of patients with Parkinson's disease (PD). The UA level was 25% lower in PD patients than in healthy individuals. This finding strongly implies that UA can be used as a biomarker for PD.
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