Journal
ACS NANO
Volume 8, Issue 12, Pages 12310-12322Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn5062386
Keywords
indocyanine green; theranostics; photothermal therapy; photodynamic therapy; synergistic effect; photoacoustic imaging
Categories
Funding
- National Natural Science Foundation of China [81301272, 81401521, 81071249, 81171446, 81371679]
- Science and Technology Foundation of Guangdong Province of China [2009A030301010]
- Science and Technology Foundation of Shenzhen [JCYJ20130401170306862, CXZZ20130506140505859]
- Key Project of Science and Technology of Guangdong [2012B090400043, 2012B090600036]
- Nanshan Innovative Technology Program [KC2013-JSJS0012A]
- Guangdong Innovation Team of Low-cost Healthcare
- SIAT Innovation Program for Excellent Young Researchers [201301]
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Phototherapy, including photodynamic therapy (PDT) and photothermal therapy (PTT), is a light-activated local treatment modality that is under intensive preclinical and clinical investigations for cancer. To enhance the treatment efficiency of phototherapy and reduce the light-associated side effects, it is highly desirable to improve drug accumulation and precision guided phototherapy for efficient conversion of the absorbed light energy to reactive oxygen species (ROS) and local hyperthermia. In the present study, a programmed assembly strategy was developed for the preparation of human serum albumin (HSA)-indocyanine green (ICG) nanoparticles (HSA-ICG NPs) by intermolecular disulfide conjugations. This study indicated that HSA-ICG NPs had a high accumulation with tumor-to-normal tissue ratio of 36.12 +/- 5.12 at 24 h and a long-term retention with more than 7 days in 4T1 tumor-bearing mice, where the tumor and its margin, normal tissue were clearly identified via ICG-based in vivo near-infrared (NIR) fluorescence and photoacoustic dual-modal imaging and spectrum-resolved technology. Meanwhile, HSA-ICG NPs efficiently induced ROS and local hyperthermia simultaneously for synergetic PDT/PTT treatments under a single NIR laser irradiation. After an intravenous injection of HSA-ICG NPs followed by imaging-guided precision phototherapy (808 nm, 0.8 W/cm(2) for 5 min), the tumor was completely suppressed, no tumor recurrence and treatments-induced toxicity were observed. The results suggest that HSA-ICG NPs generated by programmed assembly as smart theranostic nanoplatforms are highly potential for imaging-guided cancer phototherapy with PDT/PTT synergistic effects.
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