4.8 Article

Multiwalled Nanotubes Formed by Catanionic Mixtures of Drug Amphiphiles

Journal

ACS NANO
Volume 8, Issue 12, Pages 12690-12700

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/nn505688b

Keywords

self-assembly; nanotubes; catanionic mixtures; drug; camptothecin

Funding

  1. National Science Foundation [DMR 1255281]
  2. National Institutes of Health [R25CA153952, T-32CA130840, R21EB015609]
  3. Direct For Mathematical & Physical Scien
  4. Division Of Materials Research [1255281] Funding Source: National Science Foundation

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Mixing of oppositely charged amphiphilic molecules (catanionic mixing) offers an attractive strategy to produce morphologies different from those formed by individual molecules. We report here on the use of catanionic mixing of anticancer drug amphiphiles to construct multiwalled nanotubes containing a fixed and high drug loading. We found that the molecular mixing ratio, the solvent composition, the overall drug concentrations, as well as the molecular design of the studied amphiphiles are all important experimental parameters contributing to the tubular morphology. We believe these results demonstrate the remarkable potential that anticancer drugs could offer to self-assemble into discrete nanostructures and also provide important insight into the formation mechanism of nanotubes by catanionic mixtures. Our preliminary animal studies reveal that the CPT nanotubes show significantly prolonged retention time in the tumor site after intratumoral injection.

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