Journal
ACS NANO
Volume 7, Issue 9, Pages 7483-7494Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn403126e
Keywords
nanoparticle; cell cycle arrest; nanotoxicity; cationic nanoparticles; nanoparticle uptake; lysosome; cell division
Categories
Funding
- INSPIRE Programme of the Irish Government's PRTL4
- National Development Plan
- Small Collaborative project NanoTransKinetics [NMP4-2010-EU-US-266737]
- EU Seventh Framework Programme [NNP4-SL-2008-214547]
- Science Foundation Ireland (SFI) [09/RFP/MTR2425, SFI/SRC/B1155]
- Irish Research Council for Science, Engineering and Technology
- Small Collaborative project NeuroNano
- ESF Research Networking Programme EpitopeMap
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The interaction of nanoscaled materials with biological systems is currently the focus of a fast-growing area of investigation. Though many nanoparticles interact with cells without acute toxic responses, amino-modified polystyrene nanoparticles are known to induce cell death. We have found that by lowering their dose, cell death remains low for several days while, interestingly, cell cycle progression is arrested. In this scenario, nanoparticle uptake, which we have recently shown to be affected by cell cycle progression, develops differently over time due to the absence of cell division. This suggests that the same nanoparticles can trigger different pathways depending on exposure conditions and the dose accumulated.
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