Journal
ACS NANO
Volume 7, Issue 9, Pages 7442-7447Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn404501g
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Funding
- NCI NIH HHS [CA129287, R01 CA129287] Funding Source: Medline
- NIGMS NIH HHS [GM095879, R01 GM065284, R01 GM095879] Funding Source: Medline
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Nanotechnology in drug delivery has been manifested into nanoparticles that can have unique properties both in vitro and in vivo, especially in targeted drug delivery to tumors. Numerous nanoparticle formulations have been designed and tested to great effect in small animal models, but the translation of the small animal results to clinical success has been limited. Successful translation requires revisiting the meaning of nanotechnology in drug delivery, understanding the limitations of nanoparticles, identifying the misconceptions pervasive in the field, and facing inconvenient truths. Nanoparticle approaches can have real impact in improving drug delivery by focusing on the problems at hand, such as enhancing their drug loading capacity, affinity to target cells, and spatiotemporal control of drug release.
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