Journal
ACS NANO
Volume 7, Issue 10, Pages 8881-8890Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn403350v
Keywords
gold hydrosols nanoparticles; differential centrifugal sedimentation (DCS); particle sizing; monolayer-protected clusters (MPCs); FTIR; peptide-capped nanoparticles
Categories
Funding
- European Community
- CONACYT [263878, 125141]
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Differential centrifugal sedimentation (DCS) has been applied to accurately size ligand-protected gold hydrosols in the 10 to SO nm range. A simple protocol is presented to correct for particle density variations due to the presence of the ligand shell, which is formed here by either polyethylene glycol-substituted alkane thiols (PEG-alkane thiols) of different chain length or oligopeptides. The method gives reliable data for all particle sizes investigated and lends itself to rapid routine sizing of nanoparticles. Unlike TEM, DCS is highly sensitive to small changes in the thickness of the organic ligand shell and can be applied to monitor shell thickness variations of as little as 0.1 nm on particles of a given core size.
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