Journal
ACS NANO
Volume 7, Issue 8, Pages 6545-6554Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn402344v
Keywords
spherical nucleic acids; DNA hybridization reaction; DNA polymer; drug delivery; cancer therapy
Categories
Funding
- Ministry of Education, China
- National Key Scientific Program of China [2011CB911000]
- Foundation for Innovative Research Groups of NSFC [21221003]
- NSFC [21005026, 21135001]
- China National Instrumentation Program [2011YQ03012412]
- China National Grand Program [2009ZX10004-312]
- National Institutes of Health [GM079359, CA133086]
- NATIONAL CANCER INSTITUTE [R01CA133086, R21CA092581] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM079359] Funding Source: NIH RePORTER
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Based on their enhanced cellular uptake, stability, biocompatibility, and versatile surface functionalization, spherical nucleic acids (SNAs) have become a potentially useful platform in biological applications. It still remains important to expand the SNAs' toolbox, especially given the current interest in multimodal or theranostic nanomaterials, that it composites capable of multiple simultaneous applications such as imaging, sensing, and drug delivery. In this paper, we have engineered a nanoparticle-conjugated initiator that triggers a cascade of hybridization reactions resulting in the formation of a long DNA polymer as the nanoparticle shell. By employing different DNA fragments self assembled multifunctional SNAs can be constructed. Therefore, using one capped ligand, these SNAs can combine imaging fluorescent tags target recognition element and targeted delivery molecules together. Since these SNAs possess high drug loading capacity and high specificity by the incorporation of an aptamer, our approach might find potential applications in new drug development, existing drug improvement, and drug delivery for cancer therapy.
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