Journal
ACS NANO
Volume 7, Issue 12, Pages 11290-11300Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn405082y
Keywords
lanthanide; upconversion nanophosphor; multimodal imaging; tumor angiogenesis
Categories
Funding
- State Key Basic Research Program of China [2012CB932403, 2011AA-03A407]
- National Science Foundation of China [21231004, 21375024]
- Shanghai Sci. Tech. Comm. [12JC1401300, 13NM1401101]
Ask authors/readers for more resources
Multimodality imaging overcomes the shortage and incorporates the advantages of different imaging tools. Lanthanide-based nanoprobes are unique and have rich optical, magnetic, radioactive, and X-ray attenuation properties; however, simple doping of different lanthanide cations into one host can result in a material with multifunction but not the optimized properties. In this study, using NaLuF4:Yb,Tm as the core and 4 nm of Sm-153(3+)-doped NaGdF4 (half-life of Sm-153 = 46.3 h) as the shell, we developed a lanthanide-based core-shell nanocomposite as an optimized multimodal imaging probe with enhanced imaging ability. The lifetime of upconversion luminescence (UCL) at 800 nm and relaxation rate (1/T-1) were at 1044 us and 18.15 s(-1). mM(-1), respectively; however, no significant decrease in the attenuation coefficient was observed, which preserved the excellent X-ray imaging ability. The nanomaterial NaLuF4:Yb,Tm@NaGdF4(Sm-153) was confirmed to be effective and applicable for UCL imaging, X-ray computed tomography (CT), magnetic resonance imaging, and single-photon emission computed tomography (SPECT) in vivo. Furthermore, the NaLuF4:Yb,Tm@NaGdF4(Sm-153) nanoparticles were applied in tumor angiogenesis analysis by combining multimodality imaging of CT, SPEC, and confocal UCL imaging, which shows its value of multifunctional nanoparticles NaLuF4:Yb,Tm@NaGdF4(Sm-153) in tumor angiogenesis imaging.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available