Journal
ACS NANO
Volume 8, Issue 1, Pages 175-187Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn402669w
Keywords
avidin nucleic acid nanoassemblies; poly avidin; fluorescence optical imaging; in vivo diagnostics; nanomedicine; multifunctional
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Funding
- Progetto di Ateneo of the University of Padova [n.CPDA072372]
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This study describes the formulation optimization and body-cell distribution and clearance in mice of a dually fluorescent biodegradable poly avidin nanoassembly based on the novel Avidin-Nucleic-Acid-Nano-ASsembly (ANANAS) platform as a potential advancement of classic avidin/biotin-based targeted delivery. The nanoformulation circulates freely in the bloodstream; it is slowly captured by filter organs; it is efficiently deared within 24-48 h, and it is poorly immunogenic. The system displays more favorable properties than its parent monomeric avidin and it is a promising tool for diagnostic purposes for future translational aims, for which free circulation in the bloodstream, safety, multifunctionality and high composition definition are all necessary requirements. In addition, the assembly shows a time-dependent cell penetration capability, suggesting it may also function as a NP-dependent drug delivery tool. The ease of preparation together with the possibility to fine-tune the surface composition makes it also an ideal candidate to understand if and how nanoparticle composition affects its localization.
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