Journal
ACS NANO
Volume 7, Issue 7, Pages 5711-5723Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn305767t
Keywords
apatite; biomaterials; graphitic layer; human mesenchymal stem cells; nanowires; vapor solid growth
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Funding
- Pioneer Research Center Program through the National Research Foundation of Korea
- Ministry of Education, Science and Technology [2013-008421]
- Korea Institute of Energy Research (KIER) [B2-2461-08]
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Vertically aligned one-dimensional hybrid structures, which are composed of apatite and graphitic structures, can be benefidal for orthopedic applications. However, they are difficult to generate using the current method. Here, we report the first synthesis of a single-crystal apatite nanowire encapsulated in graphitic shells by a one-step chemical vapor deposition. Incipient nucleation of apatite and its subsequent transformation to an oriented crystal are directed by derived gaseous phosphorine. Longitudinal growth of the oriented apatite crystal is achieved by a vapor solid growth mechanism, whereas lateral growth is suppressed by the graphitic layers formed through arrangement of the derived aromatic hydrocarbon molecules. We show that this unusual combination of the apatite crystal and the graphitic shells can lead to an excellent osteogenic differentiation and bony fusion through a programmed smart behavior. For instance, the graphitic shells are degraded after the initial cell growth promoted by the graphitic nanostructures, and the cells continue proliferation on the bare apatite nanowires. Furthermore, a bending experiment indicates that such core shell nanowires exhibited a superior bending stiffness compared to single-crystal apatite nanowires without graphitic shells. The results suggest a new strategy and direction for bone grafting materials with a highly controllable morphology and material conditions that can best stimulate bone cell differentiation and growth.
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