Journal
ACS NANO
Volume 7, Issue 10, Pages 8385-8396Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn403908k
Keywords
1D nanoparticles; self-assembly; alignment; tobacco mosaic virus; myogenic differentiation; capillary
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Funding
- US NSF [CHE-0748690]
- Camille Dreyfus Teacher Scholar Award
- W. M. Keck Foundation
- National Natural Science Foundation of China [21128002, 21104080]
- State Key Laboratory of Polymer Physics and Chemistry of CIAC
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A facile and robust method to align one-dimensional (1D) nanoparticles (NPs) in large scale has been developed. Using flow assembly, representative rodlike nanoparticles, including tobacco mosaic vials (TMV), gold nanorods, and bacteriophage M13, have been aligned inside glass tubes by controlling flow rate and substrate surface properties. The properties of 1D NPs, such as stiffness and aspect ratio, play a critical role in the alignment. Furthermore, these hierarchically organized structures can be used to support cell growth and control the cell orientation and morphology. When C2C12 myoblasts were cultured on surfaces coated with aligned TMV, we found that nanoscale topographic features were critical to guide the cell orientation and myogenic differentiation. This method can therefore be used in the fabrication of complex assemblies with 1D NPs and have wide applications in tissue engineering, sensing, electronics, and optical fields.
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