Journal
ACS NANO
Volume 6, Issue 6, Pages 5304-5308Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn301125y
Keywords
neurotransmitters; alpha-hemolysin; nanopore; single-molecule chemistry; stochastic sensing; biosensor
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Funding
- Netherlands Organization for Scientific Research (NWO)
- Medical Research Council
- Oxford Nanopore Technologies
- MRC [G0300122] Funding Source: UKRI
- Medical Research Council [G0300122] Funding Source: researchfish
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The detection of several different neurotransmitters with the same sensor in real-time would be a powerful asset to the field of neurochemistry. We have developed a detector for a broad range of neurotransmitters including amino acids, catecholamines, and nucleotides, which relies on the reversible binding of the analytes to a copper(II) complex within an engineered protein nanopore.
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