Journal
ACS NANO
Volume 6, Issue 2, Pages 1230-1238Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn2038862
Keywords
nanoparticle; lipid membrane; translocation; cytotoxicity; computer simulation
Categories
Funding
- National Natural Science Foundation of China [91027040, 10974080]
- National Basic Research Program of China [2012CB821500]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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Nanopanicle penetration into cells is an important process In drug/gene delivery. Here, we successfully design one type of novel nanoparticles with ligands decorating its surface by dynamic bonds and find that the nanoparticle can spontaneously penetrate through membranes by using dissipative particle dynamics simulations. Moreover, the physical parameters of both ligands (for example, ligand type and density) and nanoparticles (such as size and shape) have significant effects on penetration efficiency and translocation time. Especially for nanoparticles with anisotropic shapes or asymmetric surface decoration, the penetration efficiency may reach about 80%. We also provide insights into the interaction between nanoparticles and asymmetric membranes and find that the membrane asymmetry can even increase the penetration efficiency to above 90%. The present study suggests a potential way to translocate novel nanoparticles through membranes, which may provide new ideas for future experimental nanoparticle design and drug delivery.
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