Journal
ACS NANO
Volume 6, Issue 12, Pages 10555-10561Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn3028858
Keywords
lipid bilayer; cell membrane; nanoparticles; absorption; permeability; nanotoxicity; uptake
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Funding
- Leibniz-Society (SAW Grant)
- ICREA Funding Source: Custom
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Monte Carlo simulations using the bond fluctuation method with explicit solvent reveal the mechanism of enhanced permeability of lipid bilayers induced by the adsorption of nanoparticles with controlled hydrophobicity. Simulation results indicate an adsorption transition of nanoparticles on the bilayer in a certain range of relative degree of hydrophobicity. In this range the nanoparticles can translocate through the bilayer, reversibly destabilizing the structure of the bilayer and inducing enhanced permeability for water and small solutes. This transition is broader for amphiphilic nanoparticles.
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