Journal
ACS NANO
Volume 6, Issue 6, Pages 5266-5273Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn301046w
Keywords
chitosan; magnetite; magnetic modulation; nanocube; cancer therapy; hyperthermia
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Funding
- Korean Ministry of Education, Science and Technology (MEST) [2010-0029138]
- Global Research Laboratory [20110021628]
- World Class University (WCU) of National Research Foundation (NRF) of Korea [R31-10013]
- Korean Ministry for Health, Welfare and Family Affairs
- WCU of MEST [R31-10071, R32-20026]
- National Research Foundation of Korea [R31-2012-000-10013-0, 과C6B2012] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Magnetic nanoparticles have gained significant attention as a therapeutic agent for cancer treatment. Herein, we developed chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes (Chito-FIONs) as an effective heat nanomediator for cancer hyperthermia. Dynamic light scattering and transmission electron microscopic analyses revealed that Chito-FIONs were composed of multiple 30-nm-sized FIONs encapsulated by a chitosan polymer shell. Multiple FIONs in an interior increased the total magnetic moments, which leads to localized accumulation under an applied magnetic field. Chito-FIONs also exhibited superior magnetic heating ability with a high specific loss power value (2614 W/g) compared with commercial superparamagnetic Feridex nanoparticles (83 W/g). The magnetically guided Chito-FIONs successfully eradicated target cancer cells through caspase-mediated apoptosis. Furthermore, Chito-FIONs showed excellent antitumor efficacy on an animal tumor model without any severe toxicity.
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