Journal
ACS NANO
Volume 6, Issue 8, Pages 7227-7233Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn302329c
Keywords
block copolymer micellar lithography; deep UV lithography; thermoplasmonics; cell adhesion; nanobiotechnology
Categories
Funding
- European Community
- MPG CAS joint doctoral promotion program (DPP)
- Max Planck Society
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The ability to reversibly control the interactions between the extracellular matrix (ECM) and cell surface receptors such as integrins would allow one to investigate reciprocal signaling circuits between cells and their surrounding environment. Engineering microstructured culture substrates functionalized with switchable molecules remains the most adopted strategy to manipulate surface adhesive properties, although these systems exhibit limited reversibility sophisticated preparation procedures. Here, we report a straightforward protocol to fabricate biofunctionalized micropatterned gold nanoarrays that favor one-dimensional cell migration and function as plasmonic nanostoves to physically block and orient the formation of new adhesion sites. Being reversible and not restricted spatiotemporally, thermoplasmonic approaches will open new opportunities to further study the complex connections between ECM and cells.
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