Journal
ACS NANO
Volume 6, Issue 8, Pages 6767-6775Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn3014917
Keywords
nanopore; nanofluidic transistor; DNA capture; gate manipulation; biomolecular switch
Categories
Funding
- National Institutes of Health [NIH P01 HG0000205]
- Defense Advanced Research Projects Agency [DARPA-N66001-09-1-2132]
- Natural Sciences and Engineering Research Council of Canada
Ask authors/readers for more resources
We report the use of an array of electrically gated similar to 200 nm solid-state pores as nanofluidic transistors to manipulate the capture and passage of DNA. The devices are capable of reversibly altering the rate of DNA capture by over 3 orders of magnitude using sub-1 V biasing of a gate electrode. This efficient gating originates from the counter-balance of electrophoresis and electroosmosis, as revealed by quantitative numerical simulations. Such a reversible electronically tunable biomolecular switch may be used to manipulate nucleic acid delivery in a fluidic circuit, and its development is an important first step toward active control of DNA motion through solid-state nanopores for sensing applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available