Journal
ACS NANO
Volume 5, Issue 2, Pages 1505-1512Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn103415x
Keywords
drug delivery; photothermal; MRI; supramolecular chemistry; doxorubicin; multifunctional nanoparticle
Categories
Funding
- NIH [NIH-1R21CA-133492]
- NSF [CHE-0639053]
Ask authors/readers for more resources
FeCo/graphitic carbon shell (FeCo/GC) nanocrystals (similar to 4-5 nm in diameter) with ultrahigh magnetization are synthesized, functionalized, and developed into multifunctional biocompatible materials. We demonstrate the ability of this material to serve as an integrated system for combined drug delivery, near-infrared (NIR) photothermal therapy, and magnetic resonance imaging (MRI) in vitro. We show highly efficient loading of doxorubicin (DOX) by pi-stacking on the graphitic shell to afford FeCo/GC-DOX complexes and pH sensitive DOX release from the particles. We observe enhanced intracellular drug delivery by FeCo/GC-DOX under 20 min of NIR laser (808 nm) induced hyperthermia to 43 degrees C, resulting in a significant increase of FeCo/GC-DOX toxicity toward breast cancer cells. The synergistic cancer cell killing by FeCo/GC-DOX drug delivery under photothermal heating is due to a similar to two-fold enhancement of cancer cell uptake of FeCo/GC-DOX complex and the increased DOX toxicity under the 43 degrees C hyperthermic condition. The combination of synergistic NIR photothermally enhanced drug delivery and MRI with the FeCo/GC nanocrystals could lead to a powerful multimodal system for biomedical detection and therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available