Journal
ACS NANO
Volume 5, Issue 6, Pages 4670-4678Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn200500h
Keywords
graphene; mesenchymal stem cells; cell differentiation; bone; osteogenesis
Categories
Funding
- Singapore National Research Foundation under NRF [NRFRF2008-07]
- A*STAR SERC TSRP-Integrated Nano-Photo-Bio Interface [R-144-000-275-305]
- NUS NanoCore
- Ministry of Education, Science and Technology [2010-0028075, 2010-0081966, 2011-0006268]
- National Research Foundation of Korea [2009-0093248, 2009-0093247, 2010-50171] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Current tissue engineering approaches combine different scaffold materials with living cells to provide biological substitutes that can repair and eventually improve tissue functions. Both natural and synthetic materials have been fabricated for transplantation of stem cells and their specific differentiation Into muscles, bones, and cartilages. One of the key objectives for bone regeneration therapy to be successful Is to direct stem cells' proliferation and to accelerate their differentiation in a controlled manner through the use of growth factors and osteogenic inducers. Here we show that graphene provides a promising biocompatible scaffold that does not hamper the proliferation of human mesenchymal stem cells (hMSCs) and accelerates their specific differentiation into bone cells. The differentiation rate Is comparable to the one achieved with common growth factors, demonstrating graphene's potential for stem cell research.
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