Journal
ACS NANO
Volume 5, Issue 2, Pages 1086-1094Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn102722z
Keywords
photodynamic therapy; gold nanorod; NIR fluorescence imaging; photothermal therapy; in vivo
Categories
Funding
- National Cancer Center [0710680, 0931470]
- Ministry of Knowledge Economy
- Ministry of Education, Science and Technology Republic of Korea [2010-0002209]
- Korea Evaluation Institute of Industrial Technology (KEIT) [K0006001] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Korea Health Promotion Institute [0710680-3] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2011-0002110] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A gold nanorod (GNR)-photosensitizer complex was developed for noninvasive near-infrared fluorescence imaging and cancer therapy. We showed that (a) fluorescence emission and singlet oxygen generation by AIPcS4 were quenched after complex formation with GNRs; (b) 4-fold greater intracellular uptake and better in vitro phototoxicity were observed in GNR-AIPcS(4)-treated cells than in free AIPcS(4)-treated cells; and (c) after intravenous injection of the GNR-AIPcS(4) complex, tumor sites were clearly identified on near-Infrared fluorescence images as early as 1 h after injection. The tumor-to-background ratio increased over time and was 33 at 24 h; tumor growth reduced by 79% with photodynamic therapy (PDT) alone and by 95% with dual photothermal therapy (PTT) and PDT. This novel multifunctional nanomedicine may be useful for near-infrared fluorescence imaging and PTT/PDT in various cancers.
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