Journal
ACS NANO
Volume 6, Issue 1, Pages 227-233Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn203430m
Keywords
stimulus-responsive materials; drug delivery; conductive nanoparticles; polypyrrole; controlled release
Categories
Funding
- National Defense Science and Engineering Graduate Research Fellowship
- National Science Foundation [CBET-0827806]
- American Heart Association [11IRG5450017]
- Stanford School of Medicine
- NIBIB [1R21EB012155-01A1]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [827806] Funding Source: National Science Foundation
Ask authors/readers for more resources
We describe a new temperature and electric field dual-stimulus responsive nanoparticle system for programmed drug delivery. Nanoparticles of a conducting polymer (polypyrrole) are loaded with therapeutic pharmaceuticals and are subcutaneously localized in vivo with the assistance of a temperature-sensitive hydrogel (PLGA-PEG-PLGA). We have shown that drug release from the conductive nanoparticles is controlled by the application of a weak, external DC electric field. This approach represents a novel interactive drug delivery system that can show an externally tailored release profile with an excellent spatial, temporal, and dosage control.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
