Journal
ACS NANO
Volume 5, Issue 4, Pages 3104-3112Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn2002272
Keywords
superparamagnetic iron oxide nanoparticles; transverse relaxation; contrast agent; hydrogel; pH-responsive; particle coating
Categories
Funding
- Canadian Institutes of Health Research
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Clusters of iron oxide nanoparticles encapsulated in a pH responsive hydrogel are synthesized and studied for their ability to alter the T-2-relaxivity of protons. Encapsulation of the clusters with the hydrophilic coating is shown to enhance the transverse relaxation rate by up to 85% compared to clusters with no coating. With the use of pH-sensitive hydrogel, difficulties inherent in comparing particle samples are eliminated and a clear increase In relaxivity as the coating swells is demonstrated. Agreement with Monte Carlo simulations indicates that the lower diffusivity of water inside the coating and near the particle surface leads to the enhancement. This demonstration of a surface-active particle structure opens new possibilities in using similar structures for nanoparticle-based diagnostics using magnetic resonance imaging.
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