Journal
ACS NANO
Volume 5, Issue 2, Pages 1428-1435Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn103213y
Keywords
mesoporosity; magnetic colloidal nanocrystal clusters; hydrophobic drug delivery; biocompatibility; colloidal stability
Categories
Funding
- National Science Foundation of China [20974023, 21034003, 51073040]
- National Science Foundation for Distinguished Young Scholars of China [50525310]
- Shanghai Committee of Science and Technology, China [10XD1400500]
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Fabrication of magnetic particles (MPs) with high magnetization and large surface area simultaneously is critical for the application of MPs In bioseparation and drug delivery but remains a challenge. In this article, we describe an unprecedented approach to synthesize mesoporous magnetic colloidal nanocrystal clusters (MCNCs) stabilized by poly(gamma-glutamic acid) (PGA) with high magnetization, large surface area (136 m(2)/g) and pore volume (0.57 cm(3)/g), excellent colloidal stability, prominent biocompatibility, and acid degradability. This result provides the important step toward the construction of a new family of MCNCs and demonstrates its capacity In a magnetic motor drug delivery system. Here, as an example, we explore the applicability of as-prepared mesoporous MCNCs as hydrophobic drug delivery vehicles (paclitaxel as model drug), and the resultant loading capacity is as high as 35.0 wt %. The antitumor efficacy measured by MTT assay is significantly enhanced, compared with free drugs. Thus, combined with their Inherent high magnetization, the mesoporous MCNCs pave the way for applying magnetic targeting drug carriers in antitumor therapeutics.
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