Journal
ACS NANO
Volume 5, Issue 3, Pages 1888-1896Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn102776m
Keywords
fluorescence enhancement; resonant energy transfer; plasmonic; silver core-silica shell nanoparticles; DNA sensing
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Funding
- Natural Sciences and Engineering Research Council of Canada
- Fonds Quebecois de la Recherche sur la Nature et les Technologies du Quebec
- Canadian Foundation for Innovation
- Hema-Quebec
- Canadian Blood Services
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This study describes the preparation and characterization of a DNA sensing architecture combining the molecular recognition capabilities of a cationic conjugated polymer transducer with highly fluorescent core-shell nanoparticles (NPs). The very structure of the probe-labeled NPs and the polymer-induced formation of NP aggregates maximize the proximity between the polymer donor and acceptor NPs that Is required for optimal resonant energy transfer. Each hybridization event is signaled by a potentially large number of excited reporters following the efficient plasmon-enhanced energy transfer between target-activated polymer transducer, and fluorophores located in the self assembled core-shell aggregates, resulting, in direct molecular detection of target nucleic acids at femtomolar concentrations.
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