Journal
IMMUNOTHERAPY
Volume 7, Issue 7, Pages 793-810Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/IMT.15.43
Keywords
adoptive immunotherapy; hematopoietic stem cell transplantation; T cells; viral infections
Categories
Funding
- NIH [P50CA126752, PO1 CA94237, U54 HL081007, N01-HB-10-03]
- Production Assistance for Cellular Therapies (PACT) program (NHL-BI) [HHSN268201000007C]
- Dan L Duncan Cancer Center support grant [P30CA125123]
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Hematopoietic stem cell transplantation is the treatment of choice for many hematologic malignancies and genetic diseases. However, viral infections continue to account for substantial post-transplant morbidity and mortality. While antiviral drugs are available against some viruses, they are associated with significant side effects and are frequently ineffective. This review focuses on the immunotherapeutic strategies that have been used to prevent and treat infections over the past 20 years and outlines different refinements that have been introduced with the goal of moving this therapy beyond specialized academic centers.
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