Journal
ACS NANO
Volume 5, Issue 12, Pages 9836-9844Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn2034204
Keywords
biosensing; plasmonics; Mach-Zehnder interferometry; sensitivity; figure of merit
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Funding
- National Science Foundation [CBET-1014957, ECCS-1128086]
- Directorate For Engineering
- Div Of Electrical, Commun & Cyber Sys [1128086] Funding Source: National Science Foundation
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0923370] Funding Source: National Science Foundation
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We experimentally demonstrate a plasmonic Mach-Zehnder interferometer (MZI) integrated with a microfluidic chip for ultrasensitive optical biosensing. The MZI is formed by patterning two parallel nanoslits in a thin metal film, and the sensor monitors the phase difference, induced by surface biomolecular adsorptions, between surface plasmon waves propagating on top and bottom surfaces of the metal film. The combination of a nanoplasmonic architecture and sensitive interferometric techniques in this compact sensing platform yields enhanced refractive index sensitivities greater than 3500 nm/RIU and record high sensing figures of merit exceeding 200 in the visible region, greatly surpassing those of previous plasmonic sensors and still hold potential for further improvement through optimization of the device structure. We demonstrate real-time, label-free, quantitative monitoring of streptavidin-biotin specific binding with high signal-to-noise ratio in this simple, ultrasensitive, and miniaturized plasmonic biosensor.
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