Journal
ACS NANO
Volume 5, Issue 6, Pages 5263-5272Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn201477y
Keywords
nanoparticles; emulsion polymerization; polysulfide; enzyme catalysis; cargo; controlled release
Categories
Funding
- Army Research Office [W911NF-09-C-0156]
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Poly(propylene sulfide) nanoparticles (<150 nm) have been synthesized by an anionic, ring-opening emulsion polymerization. Upon exposure to parts per million (ppm) levels of oxidizing agent (NaOCl), hydrophobic polysulfide particles are oxidized to hydrophilic polysulfoxides and polysulfones. Utilizing this mechanism, the encapsulation of hydrophobic molecular cargo, including Nile red and Reichardt's dye, within polysulfide nanoparticles has been characterized by a variety of microscopic and spectroscopic methods and its release demonstrated via chemical oxidation. Moreover, release of cargo has been enzymatically driven by oxidoreductase enzymes such as chloroperoxidase and myeloperoxidase in the presence of low concentrations of sodium chloride (200 mM) and hydrogen peroxide (500 mu M). This oxidation-driven mechanism holds promise for controlled encapsulation and release of a variety of hydrophobic cargos.
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