Journal
ACS NANO
Volume 5, Issue 5, Pages 3585-3590Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn201132a
Keywords
gold; nanoparticle; phospholipid; membrane; vesicle; injection; drug-delivery
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Funding
- DFG through the Nanosystems Initiative Munich (NIM)
- ERC
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We propose and demonstrate a new method of an all-optical, contactless, one-step injection of single gold nanoparticles through phospholipid membranes. The method is based on the combination of strong optical forces acting on and simultaneous optical heating of a gold nanoparticle exposed to laser light tuned to the plasmon resonance of the nanoparticle. A focused laser beam captures single nanoparticles from the colloidal suspension, guides them toward a phospholipid vesicle and propels them through the gel-phase membrane, resulting in the nanoparticle internalization into the vesicle. Efficient resonant optical heating of the gold nanoparticle causes a pore to form in the gel-phase membrane, a few-hundred nanometers in size, which remains open for several minutes.
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