Journal
ACS NANO
Volume 5, Issue 11, Pages 8649-8655Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn202291k
Keywords
nanoparticles; cisplatin; drug delivery; nucleoside-lipids; cancer
Categories
Funding
- French National Agency (ANR) [ANR-08-EBIO-013-01]
- Army Research Office
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The use of delivery vehicles to selectively transport anticancer agents to tumors is very attractive to address both toxicity and efficacy issues. We report a novel approach based on hybrid nucleoside lipids allowing the efficient encapsulation and delivery of cisplatin. We demonstrate that the nucleoside polar heads guide the self-assembly of the aggregates into highly loaded and stable nanoparticles. The nanoparticles, which are efficient vehicles for the delivery of cisplatin into different sensitive and resistant cancer cell lines, can overcome the disadvantages and limitations of drug delivery systems previously reported.
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