Journal
ACS NANO
Volume 5, Issue 8, Pages 6643-6650Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn2021293
Keywords
drug delivery; nanovectors; paclitaxel; targeted; noncovalent
Categories
Funding
- University of Texas Health Science Center, Houston (Department of Defense) [W8XWH-07-2-0101]
- Department of Defense [W81XWI-1-08-2-0141, W81XWH-08-2-0143]
- Nanoscale Science and Engineering Initiative of the National Science Foundation under NSF [EEC-0647452]
- University of Texas M.D. Anderson Cancer Center
- NIH Cancer Center [CA16672]
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Current chemotherapeutics are characterized.-by efficient tumor cell-killing and severe side effects mostly derived from off-target toxicity. Hence targeted delivery of these drugs. to tumor cells is actively sought. We previously demonstrated that poly(ethylene glycol)-functionalized carbon nanovectors are able to sequester paclitaxel, a widely used hydrophobic cancer drug, by simple physisorption and thereby deliver the drug for killing of cancer cells. The cell-killing When these drug-loaded carbon nanoparticles were used was, equivalent to. when a commercial formulation of paclitaxel was used.. Here we show that by further mixing the. drug-loaded nanoparticles with Cetuximab, a monodonal antibody that recognizes the epidermal growth factor receptor (EGFR), paclitaxel is preferentially targeted to EGFR+ tumor cells in vitro. This supports progressing to in vivo studies. Moreover, the construct Is unusual In that all three components are assembled through noncovalent interactions. Such noncovalent assembly could enable high-throughput screening of drug/antibody combinations.
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