Journal
ACS NANO
Volume 5, Issue 11, Pages 9264-9270Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn2035654
Keywords
plant cell; single-walled carbon nanotubes; fluorescein isothiocyanate; diffusional mobility; subcellular distribution
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Funding
- New Energy and Industrial Technology Development Organization (NEDO) of Japan
- Japan Society for the Promotion of Science (JSPS)
- Center National de la Recherche Scientifique
- European Union [HEALTH-2007-201587]
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As nanoparticles can cross different cellular barriers and access different tissues, control of their uptake and cellular fate presents a functional approach that will be broadly applicable to nanoscale technologies in cell biology. Here we show that the trafficking of single-walled carbon nanotubes (SWCNTs) through various subcellular membranes of the plant cell is facilitated or inhibited by attaching a suitable functional tag and controlling medium components. This enables a unique control over the uptake and the subcellular distribution of SWCNTs and provides a key strategy to promote their cellular elimination to minimize toxicity. Our results also demonstrate that SWCNTs are involved in a carrier-mediated transport (CMT) inside cells; this is a phenomenon that scientists could use to obtain novel molecular insights into CMT, with the potential translation to advances in subcellular nanobiology.
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