Journal
ACS NANO
Volume 5, Issue 6, Pages 4965-4973Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn201065y
Keywords
polyethylene oxide; poly(ethylene glycol); ligands; water-soluble; CdSe/CdS/ZnS; quantum dots; photoluminescence
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Funding
- Deutsche Forschungsgemeinschaft [DFG-SPP 1313, WE2059/8-1]
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In this contribution a facile, one-step synthesis of tridentate thiol-functionalized PEO ligands and their ability to stabilize CdSe/CdS/ZnS core-shell-shell nanoparticles In aqueous media are described. The PEO-coated quantum dots show colloidal stability as well as preserved fluorescence even at very low concentrations of a few nM. For improved ligand attachment and enhanced fluorescence properties a method for ligand exchange was developed, which includes formation of a ligand zinc complex before the actual exchange reaction. The stability and fluorescence properties in various aqueous buffers and cell media and at pH values down to pH 3 were investigated. The firm binding of the tridentate ligands to the particle surface makes this ligand particle system a promising tool for biological applications. In addition, activation of the ligands' terminal hydroxyl group for covalent biofunctionalization by esterification with succinic acid is reported.
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