Journal
ACS NANO
Volume 4, Issue 2, Pages 1033-1041Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn901181c
Keywords
hollow gold nanospheres; doxorubicin; triggered release; near-infrared light; antitumor activity
Categories
Funding
- National Cancer Institute [R01 CA119387]
- John S. Dunn Foundation
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We report dual-functional hollow gold nanospheres (HAuNS, similar to 40-nm diameter) capable of mediating both photothermal ablation of cancer cells and drug release upon near-infrared (NIR) light irradiation. As high as 63% DOX by weight (similar to 1.7 mu g DOX/mu g Au) could be loaded to polyethylene glycol (PEG)-coated HAuNS since DOX was coated to both the outer and the inner surfaces of HAuNS. Irradiation with NIR laser induced photothermal conversion, which triggered rapid DOX release from DOX-loaded HAuNS. The release of DOX was also pH-dependent, with more DOX released in aqueous solution at lower pH, Significantly greater cell killing was observed when MDA-MB-231 cells incubated with DOX-loaded HAuNS were irradiated with NIR light, attributable to both HAuNS-mediated photothermal ablation and cytotoxicity of released free DOX.
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