Journal
ACS NANO
Volume 4, Issue 6, Pages 3023-3032Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nn901657w
Keywords
porous silicon; nanoparticles; oral delivery; cytotoxicity; biodistribution; Caco-2 cells
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Funding
- Academy of Finland [127099, 123037, 122314, 115385]
- Jenny and Antti Wihuri Foundation
- University of Helsinki
- Academy of Finland (AKA) [122314, 123037, 127099, 115385, 123037, 127099, 115385, 122314] Funding Source: Academy of Finland (AKA)
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Porous silicon (PSI) particles have been studied for the effects they elicit in Caco-2 and RAW 264.7 macrophage cells in terms of toxicity, oxidative stress, and inflammatory response. The most suitable particles were then functionalized with a novel F-18 label to assess their biodistribution after enteral and parenteral administration in a rat model. The results show that thermally hydrocarbonized porous silicon (THCPSi) nanoparticles did not induce any significant toxicity, oxidative stress, or inflammatory response in Caco-2 and RAW 264.7 macrophage cells. Fluorescently labeled nanoparticles were associated with the cells surface but were not extensively internalized. Biodistribution studies in rats using novel F-18-labeled THCPSi nanoparticles demonstrated that the particles passed intact through the gastrointestinal tract after oral administration and were also not absorbed from a subcutaneous deposit. After intravenous administration, the particles were found mainly in the liver and spleen, indicating rapid removal from the circulation. Overall, these silicon-based nanosystems exhibit excellent in vivo stability, low cytotoxicity, and nonimmunogenic profiles, ideal for oral drug delivery purposes.
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